Patients requiring surgical treatment under general anesthesia.
Conditions
Interventions
S1 group:0.1ug / kg sufentanil
S2 group:0.3ug / kg sufentanil
S3 group:0.5ug/kg sufentanil
Sponsors
Hangzhou Yuhang Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, < 65 years; 2. The operation is required under general anesthesia; 3. American Society of Anesthesiologists (ASA) I-II; 4. Body mass index (BMI) was between 18-25 kg/m^2; 5. To sign an informed consent form indicating willingness to participate in the research process and voluntarily agree to be a subject.
Exclusion criteria
Exclusion criteria: 1. Allergic to propofol or have contraindications to the use of propofol (soybean allergy); 2. Preoperative disturbance of consciousness or chronic pain with long-term use of analgesics, psychotropic drugs (including opioids, NSAIDs, sedatives, antidepressants); 3. Expected difficult airway or abnormal anesthesia history; 4. Patients with tumor, severe cardiovascular and cerebrovascular diseases, etc.; 5. Sedatives, antiemetic drugs, antipruritic drugs, or monoamine oxidase inhibitors or antidepressants were used within 24 hours before surgery; 6. Researchers who do not agree to participate or are participating in other drug trials; 7. Emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 of cycloprofen and their 95% confidence intervals; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs (BP, HR, SpO2);Pain intensity;Incidence of hypotension during induction;Incidence of bradycardia;Incidence of respiratory depression;Incidence of hypoxemia;Incidence of myoclonus;Incidence of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactQiu Yanzhen
Hangzhou Yuhang Second People's Hospital
Outcome results
None listed