post-stroke visual spatial neglect
Conditions
Interventions
Control group of patients with visuospatial neglect:The left parietal lobe (l-ppc) was selected as the stimulation site for TMS stimulation.
Experimental group of patients with visuospatial neglect:TMS-EEG was used to calculate the connectivity index of the frontal parietal network, and the interhemispheric interaction index (IHI) was used
Healthy subjects:Single high frequency repetitive transcranial magnetic stimulation
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The inclusion criteria of healthy subjects were as follows: (1) age: 18 – 80 years old, male or female; (2) The subject voluntarily participated in the study and signed the informed consent; (3) Right handedness; (4) No TMS contraindications such as metal implants and cardiac pacemakers; (5) The history of drug use affecting brain function was not combined. 2.The inclusion criteria of patients with visuospatial neglect included: (1) age between 18 and 80 years; (2) Right hemisphere stroke confirmed by CT or MRI (including cerebral infarction and cerebral hemorrhage); (3) Right handedness; (4) ; (5) Patients and / or family members provided informed consent.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for healthy subjects: (1) history of neurological or psychiatric diseases; (2) A history of epilepsy, high intracranial pressure, and craniocerebral surgery; (3) Pregnant or lactating women; (4) Complicated with severe heart disease, liver and kidney dysfunction and other systemic diseases; (5) Those who cannot cooperate with the completion of the research process (including but not limited to: communication barriers, inability to maintain the specified posture, etc.). 2.The exclusion criteria for patients with visuospatial neglect included: (1) the presence of new infarcts, hemorrhagic lesions or other conditions suggestive of clinical deterioration; (2) Severe uncorrectable visual impairment or visual field defect; (3) Hemianopia confirmed by perimetry; (4) ; (5) Presence of metal implants; (6) MMSE score <= 17; (7) Uncooperative behavior during inspection; (8) Recent use of tricyclic antidepressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paper and pencil scale (line bisector, line segment elimination, circle elimination);The difference of the comprehensive neural response scores (the sum of plv_auc and cd_auc) of the three stimulation targets before and after the intervention.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Propagation between signal cortices;oscillatory activity;TMS evoked potentials (TEPs);Characteristics of functional connectivity network in resting state; | — |
Countries
China
Contacts
Public ContactLinlin Ye
Xuanwu Hospital Capital Medical University
Outcome results
None listed