Helicobacter pylori infection
Conditions
Interventions
Amoxicillin group:None
Cefuroxime group:None
Sponsors
The First Affiliated Hospital, Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years and <= 75 years, regardless of gender; 2. Helicobacter pylori infection confirmed by any of the following methods: 13C/14C urea breath test, gastric biopsy histopathology, or H. pylori culture; 3. No previous H. pylori eradication treatment, or failure of prior eradication treatment with an interval of = 6 months since the last treatment; 4. Voluntary participation in this study and provision of written informed consent; 5. Patients with penicillin allergy (clear history of allergy or positive penicillin skin test) are enrolled in the cefuroxime group, while patients without penicillin allergy are enrolled in the amoxicillin group based on clinical treatment preference.
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics, bismuth, H2-receptor antagonists, proton pump inhibitors (PPIs), tegoprazan, or other acid-suppressing drugs within 4 weeks prior to treatment. 2. Allergy to any drug used in this study (tegoprazan, amoxicillin, cefuroxime, doxycycline, or bismuth). 3. Pregnancy or breastfeeding, or planning to become pregnant during the study period. 4. History of gastrectomy, gastric cancer, recent bleeding (within 4 weeks) from gastroduodenal ulcers, or signs of active bleeding. 5. Severe hepatic or renal dysfunction (ALT/AST > 3 times the upper limit of normal, serum creatinine > 133 µmol/L), cardiovascular disease (such as heart failure, severe arrhythmia), immunodeficiency, malignant tumors, or other severe conditions that may affect study evaluation. 6. Presence of psychiatric disorders, cognitive impairment, or inability to cooperate with follow-up and data collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions;Medication compliance; | — |
Countries
China
Contacts
Public ContactYan Zhang
The First Affiliated Hospital, Ningbo University
Outcome results
None listed