Postpartum Hemorrhage
Conditions
Interventions
control group:Oxytocin + Placebo
After delivery of the second fetus, oxytocin 10 IU was administered intravenously in 500 mL of normal saline, concurrently with a placebo injection given intramuscular
Intervention group:Oxytocin + Ergometrine
After delivery of the second fetus, oxytocin 10 IU was administered intravenously in 500 mL of normal saline, and Ergometrine 0.2 mg was given intramuscularly
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women aged >= 18 years; 2. Twin pregnancy confirmed by ultrasound; 3. Gestational age >= 34+0 weeks; 4. Elective cesarean section (non emergency); 5. Preoperative hemoglobin >= 90g/l; 6. ASA class II-III; 7. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Known allergy to oxytocin or ergometrine; 2. Contraindications for ergometrine use (such as hypertension, cardiovascular disease, etc.); 3. Placenta previa; Placenta accreta; Suspected placenta accreta; 4. Known coagulation dysfunction or platelet count = 5cm; or multiple fibroids with more than 3 and a single fibroid >= 2cm; 7. Polyhydramnios (amniotic fluid index > 24cm); 8. Macrosomia (estimated weight of any fetus > 4000g); 9. Other operations (such as ovarian cyst removal, uterine fibroids removal, etc.) are required during the operation; 10. Participating in other clinical studies; 11. The researcher believes that it is not suitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of the composite outcome of postpartum hemorrhage and related complications within 24 hours postpartum.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severe postpartum hemorrhage (>=1000 mL) within 24 hours postpartum.;Proportion of patients requiring additional second?line uterotonics.;The magnitude of hemoglobin decrease at 24 and 48 hours postoperatively.;Cardiovascular adverse events;Quality of postoperative recovery; | — |
Countries
China
Contacts
Public ContactHongbo Qi
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed