Prediabetes
Conditions
Interventions
Pre-diabetic observation group:None
Healthy control group:None
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in this study, sign a written informed consent form, and be able to follow the research protocol for regular follow-up; 2. Age >= 35 years old and Chinese Diabetes Risk Score >= 25 points (i.e., traditional factor population with high risk of diabetes); 3. Normal blood glucose range, that is, at baseline, through fasting blood glucose or HbA1c or OGTT test, the blood glucose is normal (i.e., fasting blood glucose < 6.1 mmol/L and HbA1c < 5.7% and OGTT 2-hour blood glucose < 7.8 mmol/L).
Exclusion criteria
Exclusion criteria: 1. Diagnosed with diabetes or prediabetes: Previously had a history of diabetes or met the diagnostic criteria for diabetes at the baseline screening (fasting blood glucose >= 7.0 mmol/L or HbA1c >= 6.5%) or the criteria for prediabetes (i.e., impaired fasting glucose: 6.1 - 6.9 mmol/L; and/or impaired glucose tolerance: 7.8 - 11.0 mmol/L; and/or HbA1c 5.7% - 6.5%); 2. Diseases or conditions severely affecting blood sugar: Severe heart, liver, or kidney dysfunction (such as NYHA cardiac function III-IV grade, liver cirrhosis, renal failure eGFR < 30 mL/min/1.73m^2); 3. Severe complications or comorbidities: Recently (within 6 months) experienced major vascular events (such as myocardial infarction, stroke); 4. Have a malignant tumor and are currently in an active stage or undergoing treatment; 5. Have severe mental or cognitive disorders and are unable to cooperate with the study; 6. Pregnant women, lactating women, or those planning to become pregnant within the next year; 7. Have a severe allergic or intolerant reaction to CGM sensor patches; 8. Plan to move out of the research center's coverage area within the next 1 year and are unable to complete follow-up; 9. Unable or unwilling to use smartphones or smart devices, which will affect data collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral Glucose Tolerance Test;Body fat percentage;Visceral fat area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;Glycated albumin;Fat free mass index;Body mass index;Muscle mass; | — |
Countries
China
Contacts
Public ContactXinhua Xiao
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking
Outcome results
None listed