Locally advanced nasopharyngeal carcinoma
Conditions
Interventions
Gold Standard:The reference standard is the contrast-enhanced MRI of the head and neck performed at 3 months after the completion of concurrent chemoradiotherapy, evaluated according to the RECIST 1.1
Index test:The semi-quantitative parameters (TMR, TBR, SUVmax, SUVmean, MTV, TLG, etc.) obtained from 18F-FMISO PET/CT, 18F-FAPI PET/CT and 18F-FDG PET/CT before treatment were used as the index tests
Sponsors
Affiliated Tumor Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Pathologically confirmed as nasopharyngeal squamous cell carcinoma, with UICC/AJCC 9th edition staging of anyTN3M0 or T4N0-3M0; 2.Patients with an ECOG performance status score of 0-1 can tolerate radiotherapy, chemotherapy, and imaging examinations; 3.There was no previous history of other tumors, and no anti-tumor treatment had been received. 4.Voluntarily participate in this study and sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of other malignant tumors were excluded; 2.Patients who did not complete the full treatment course or withdrew midway were excluded; 3.Patients with severe organ dysfunction and inability to cooperate with examinations were excluded;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-Free Survival;Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| PET quantitative and semi-quantitative parameters; | — |
Countries
China
Contacts
Public ContactHai Liao
Affiliated Tumor Hospital of Guangxi Medical University
Outcome results
None listed