postoperative sleep disturbance, postoperative pain, and postpartum depression.
Conditions
Interventions
Esketamine group:Intravenous esketamine injection alone after fetal delivery
Control group:Simple local anesthesia protocol
Dexmedetomidine combined with Esketamine group:Anesthesia protocol of local anesthesia combined with dexmedetomidine, plus intravenous esketamine injection after fetal delivery
Sponsors
Hefei Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–45 years; 2.Body mass index (BMI): 21–35 kg/m²; 3.American Society of Anesthesiologists (ASA) physical status classification: Class ?–?.
Exclusion criteria
Exclusion criteria: 1.Contraindications to DEX and ESK use, including: Severe cardiovascular and cerebrovascular diseases, severe gestational hypertension, preeclampsia or eclampsia; 2.Patients with a full stomach or elevated intraocular pressure; 3.Patients with uncontrolled hyperthyroidism; 4.Patients with severe bradycardia on electrocardiography (ECG) 5.Individuals with a history of drug abuse; 6.Patients with intellectual disabilities; 7.Those who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality on postoperative days 1-3;Sleep efficiency on postoperative days 1-3; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity after cesarean section;Incidence of postpartum depression;Incidence of postoperative adverse drug reactions;Analgesic effect;Serological markers, including brain?derived neurotrophic factor (BDNF) and inflammatory cytokines (IL?6 and TNF?a), etc.; | — |
Countries
China
Contacts
Public ContactJuting Zhu
Hefei Maternal and Child Health Hospital
Outcome results
None listed