Critical Illness
Conditions
Interventions
Quadriceps Muscle Thickness Decline Trajectory Group:No intervention.
Based on longitudinal changes in quadriceps muscle thickness, a group?based trajectory model (GBTM) was applied to identify distin
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. Admission to the ICU and receipt of invasive mechanical ventilation; 3. Expected duration of mechanical ventilation >= 48 hours; 4. Expected ICU stay >=5 days; 5. Ability to undergo at least two quadriceps muscle ultrasound assessments after enrollment.
Exclusion criteria
Exclusion criteria: 1. Pre-existing severe neuromuscular disorders prior to ICU admission; 2. Amputation or severe lower-limb trauma that interferes with ultrasound assessment; 3. Local infection, open wounds, or severe edema of the quadriceps region preventing ultrasound measurement; 4. Pregnant patients; 5. Death or withdrawal of life-sustaining treatment within 24 hours of ICU admission; 6. Inability to obtain primary outcome data during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 60-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Length of ICU stay;Total hospital stay;ICU mortality;Success rate of weaning from mechanical ventilation;Rate of change in quadriceps muscle thickness;Trajectory patterns of quadriceps muscle thickness changes; | — |
Countries
China
Contacts
Public ContactYuntian Xu
Hefei First People's Hospital
Outcome results
None listed