Hypoxemia
Conditions
Interventions
Remimazolam group:Remimazolam was used for sedation during both the induction and maintenance phases.
Propofol group:Propofol was used for sedation during both the induction and maintenance phases.
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years old (inclusive of boundary values). 2. Body Mass Index >= 30 kg/m^2. 3. ASA classification <= III grade. 4. Intending to undergo elective laparoscopic sleeve gastrectomy under general anesthesia. 5. Voluntarily participating in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with severe cardiac diseases (including heart failure, angina pectoris, myocardial infarction, or severe arrhythmias). 2.Patients with severe pulmonary diseases (including poorly controlled asthma, chronic obstructive pulmonary disease, interstitial lung disease, pulmonary embolism, pulmonary edema, or lung cancer). 3.Patients with current diagnosis of liver cirrhosis, liver failure, or chronic kidney disease. 4.Known allergy to remimazolam or propofol. 5.Patients deemed by the investigator to require postoperative admission to the intensive care unit. 6.Long-term benzodiazepine use. 7.Vulnerable populations, including individuals with psychiatric disorders, cognitive impairment, critically ill patients, pregnant women, and illiterate individuals. 8.Any other condition that, in the opinion of the investigator, makes the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time-weighted average value of the SpO2/FiO2 ratio within the first 30 minutes after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of high?flow oxygen therapy requirement within the first 30 minutes after extubation.;Incidence of severe hypoxemia within the first 30 minutes after extubation (SpO210 s).;Incidence of reintubation within the first 30 minutes after extubation.;Incidence of pulmonary complications during hospitalization (respiratory failure, acute respiratory distress syndrome, pulmonary edema, atelectasis, etc.).;Length of stay in the post?anesthesia care unit (PACU).;Incidence of general airway intervention requirement within the first 30 minutes after extubation (manual increase in oxygen flow, ordinary face mask ventilation, oxygen reservoir mask ventilation, et;Time to tracheal extubation (from the end of anesthesia to extubation).;Incidence of hypoxemia within the first 30 minutes after extubation (85% 10 s).;Incidence of ICU admission due to hypoxemia.;Incidence of delayed extubation.;Incidence of subclinical respiratory depression within the first 30 minutes after extubation (90% 10 s).; | — |
Countries
China
Contacts
Public ContactChen Gang
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed