Acute Acquired Comitant Esotropia
Conditions
Interventions
Control Group:Botulinum toxin type A injection therapy
Experimental Group:Botulinum toxin type A injection combined with comprehensive vision function training
Sponsors
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 35 years old; 2.Acute onset of esotropia with diplopia or visual confusion; 3.Difference in strabismic angle across different gaze directions <= 5 prism diopters (?); 4.Essentially normal ocular motility in all directions; 5.Distance and near strabismic angles measured by prism and alternate cover test (PACT) both <=25?; 6.Willing to sign the informed consent form voluntarily and to complete follow-up visits and relevant examinations as per the study protocol; 7.Female participants of childbearing age must agree to take strict and effective contraceptive measures during the study period.
Exclusion criteria
Exclusion criteria: 1.Best corrected visual acuity 1.5D with reduction of strabismic angle >= 10? after full correction; 4.Active ocular infection or intraocular inflammation; 5.Prior orbital CT showing abnormality or displacement of extraocular muscles; 6.History of ocular surgery or previous botulinum toxin injection for strabismus; 7.Neuromuscular disorders; 8.Use of medications affecting neuromuscular junction; 9.Poorly controlled hypertension or diabetes mellitus; 10.Bleeding disorders or use of anticoagulant/antiplatelet medications; 11.Pregnant or lactating women, or those planning pregnancy during the treatment/follow-up period; 12.Severe mental illness or cognitive impairment that prevents understanding or compliance with treatment and follow-up; 13.Known allergy to botulinum toxin or any component of the formulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Cure Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical measures;Adverse reactions related to botulinum toxin injection;Adult Strabismus-20, AS-20;Adverse reactions related to vision function training;Clinical cure; | — |
Countries
China
Contacts
Public ContactJingchang Chen
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Outcome results
None listed