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Precision rTMS Neuromodulation Based on Corticomuscular Coupling Assessment: A Comparative Study of Mechanisms Underlying Upper Limb Functional Recovery in Stroke Patients Using Different Frequency Protocols

Precision rTMS Neuromodulation Based on Corticomuscular Coupling Assessment: A Comparative Study of Mechanisms Underlying Upper Limb Functional Recovery in Stroke Patients Using Different Frequency Protocols

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127036
Enrollment
Unknown
Registered
2026-06-23
Start date
2026-06-29
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

High frequency rTMS:While receiving conventional rehabilitation treatment, receive high-frequency (10 Hz) rTMS stimulation for the primary motor cortex hand area (M1) on the affected side.
Low frequency rTMS:While receiving routine rehabilitation treatment, receive low-frequency (1 Hz) rTMS stimulation for the primary motor cortex hand area (M1) on the healthy side.
Fake stimulation group:Using a special fake stimulation coil, its appearance, operation sound, vibration sensation and coolant flow sound are exactly the same as the real coil, but the magnetic field

Sponsors

The First Affiliated Hospital of Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Confirmed as stroke by CT or MRI, accompanied by upper limb motor dysfunction; 2. The stroke attack lasts for more than a month; 3. No obvious visual or auditory disorders; 4. Able to independently complete the flexion and extension of the elbow joint within a certain range; 5. There is no other motor dysfunction of both upper limbs before the stroke; 6. Voluntarily cooperate with the experiment.

Exclusion criteria

Exclusion criteria: 1 There are transcranial magnetic contraindications: those with seizures or a history of family epilepsy, those with severe heart disease or other internal diseases, those with bleeding tendency, local open wounds and infected people; 2 Those with severe depression, mania and other mental diseases; 3 those with severe heart, lung, liver, kidney failure and other complications; 4 pregnant women, children

Design outcomes

Primary

MeasureTime frame
Electroencephalogram;Electromyogram;

Secondary

MeasureTime frame
Fugl-Meyer Assessment for Upper Extremity (FMA-UE);Action Research Arm Test (ARAT);Modified Barthel Index (MBI);Nine-Hole Peg Test (NHPT);

Countries

China

Contacts

Public ContactLin Runhui

the First Affiliated Hospital o f Fujian Medical University

624892506@qq.com+86 158 8008 9171

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 3, 2026