Pancreatic cancer
Conditions
Interventions
Trial group:Lidocaine intravenous infusion: Intravenous injection of 1.5 mg/kg based on ideal body weight (IBW) during anesthesia induction, completed within 10 minutes, followed by continuous infusio
Placebo group:Placebo (0.9% saline): Intravenous injection of saline 1.5 ml/kg during anesthesia induction (mimicking volume and rate of lidocaine bolus), followed by continuous infusion of saline at
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 80; 2.American Society of Anesthesiologists (ASA) classification of grades I-III; 3.Patients diagnosed with pancreatic cancer (or other periampullary cancers) through imaging and/or pathology, who plan to undergo definitive radical pancreatectomy (such as pancreaticoduodenectomy, distal pancreatectomy, etc.) within a limited timeframe; 4.Agree to use patient-controlled analgesia (PCA) device for postoperative pain management; 5.Sign the informed consent form and voluntarily comply with the research protocol and follow-up requirements;
Exclusion criteria
Exclusion criteria: 1.weight under 40kg; 2.Combined with other active malignant tumors; 3.Preoperative assessment indicated palliative surgery or exploratory surgery without the possibility of radical resection; 4.Autoimmune disease; 5.Severe hepatic insufficiency (aspartate aminotransferase or alanine aminotransferase or bilirubin > 2.5 times the upper limit of normal); 6.Severe renal insufficiency (serum creatinine =186µmol/L or creatinine clearance rate 3 months) regular use of opioids;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-Free Survival(DFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rate of major complications within 30 days after surgery;Total consumption of opioids;Postoperative hospitalization duration;Postoperative pain score, postoperative sleep score;Recurrence/metastasis rate;Incidence of postoperative cognitive dysfunction;Dynamic changes of perioperative inflammatory/immune biomarkers;Postoperative ICU admission rate;First exhaust time;Overall Survival(OS);Incidence of postoperative delirium; | — |
Countries
China
Contacts
Public ContactZhang Liyun
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed