Stroke
Conditions
Interventions
Case series:Not applicable
Sponsors
The Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years. 2. First-ever acute ischemic stroke, diagnosed according to the criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and confirmed by cranial CT or MRI. 3. Time from stroke onset to hospital admission <= 72 hours. 4. Good pre-stroke functional status (modified Rankin Scale score mRS <= 1). 5. The patient or their legally authorized representative fully understands the study and provides written informed consent.
Exclusion criteria
Exclusion criteria: 1. Intracerebral hemorrhage, subarachnoid hemorrhage, transient ischemic attack (TIA), or other non-ischemic cerebrovascular diseases; 2. A definite diagnosis of major psychiatric disorders (e.g., depression, bipolar disorder, schizophrenia, anxiety disorder) before stroke, or current use of related psychotropic medications; 3. Presence of severe infection (e.g., body temperature >38.0°C, or procalcitonin [PCT] >0.5 ng/mL), malignant tumor, severe liver or kidney dysfunction, or autoimmune disease requiring immunosuppressive therapy at the time of admission; 4. Severe aphasia, impaired consciousness, or cognitive impairment that, in the investigator's judgment, precludes completion of depression rating scales; 5. Expected survival of less than 6 months; 6. Current participation in another clinical trial that may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6;p-STAT3;S100B;Single nucleotide polymorphism, SNP; | — |
Countries
China
Contacts
Public ContactShi Hongting
The Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed