Chronic kidney disease, renal fibrosis
Conditions
Interventions
CKD:Observational study, no specific intervention plan
Health:Observational study, no specific intervention plan
Sponsors
Ningbo Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: CKD Group: 1. Age 18-75 years; 2. CKD (eGFR = 3 months) as defined by the KDIGO guidelines and with CKD stage II-IV; 3. Condition is stable, no acute kidney injury in the past 4 weeks; 4. Signed written informed consent. Healthy Control Group: 1. Age and gender roughly matched with the CKD group; 2. No history of kidney disease; 3. eGFR >= 90 mL·min^1·1.73 m^2, normal urinalysis; 4. No systemic inflammation or immune-related diseases; 5. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Inclusion of acute infections, fevers or inflammatory diseases; 2. Inclusion of autoimmune diseases, malignant tumors; 3. Severe liver dysfunction, active chronic hepatitis B or C, HIV-infected individuals; 4. Use of immunosuppressants, glucocorticoids or biologics, or antibiotics within the last 3 months; 5. Pregnant or lactating women; 6. Individuals with severe mental disorders or those who cannot cooperate with follow-up; 7. Other conditions deemed unsuitable for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum IL4I1; | — |
Secondary
| Measure | Time frame |
|---|---|
| the correlations of eGFR, Scr, BUN and IL4I1 level; | — |
Countries
China
Contacts
Public ContactZHAO YU
Ningbo Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed