Intraoperative hemodynamic disturbance during gynecological surgery
Conditions
Interventions
Group A: Ciprofol group in Phase 1:The initial dose of ciprofol was 0.4 mg/kg, administered as a uniform intravenous bolus over 30 seconds. The dose step for the ciprofol group was 0.05 mg/kg. The tri
Group B: Propofol group in Phase 1:The initial dose of propofol was 1.5 mg/kg, administered via intravenous bolus at a constant rate over 30 seconds. The dose step for the propofol group was 0.25 mg/k
Group C: Ciprofol group in Phase 2:Both groups were given the ED50 determined in Phase1 via uniform intravenous injection over 30 seconds. PI, MAP and HR were recorded at 1 min, 2 min and 3 min after
Group P: Propofol group in Phase 2:Both groups were given the ED50 determined in Phase1 via uniform intravenous injection over 30 seconds. PI, MAP and HR were recorded at 1 min, 2 min and 3 min after
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 22 to 45 years. 2. Scheduled for elective gynecological surgery under general anesthesia. 3. ASA physical status class ?–?. 4. Body mass index (BMI): 18–28 kg/m².
Exclusion criteria
Exclusion criteria: 1.Patients with allergy to ciprofol, propofol or their ingredients. 2.Patients complicated with cardiovascular diseases or peripheral vascular diseases (e.g., Raynaud's syndrome). 3.Anemia (Hb < 90 g/L) or hypoalbuminemia (albumin < 30 g/L). 4.Preoperative use of vasoactive drugs, calcium channel blockers, ß-receptor blockers or anticholinergic agents. 5.History of diabetes mellitus, neurological or psychiatric disorders. 6.Abnormal hepatic and renal function. 7.History of drug abuse, anxiety or depression. 8.Fingernail polish on the monitored finger, abnormal skin temperature or peripheral circulatory disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perfusion index (PI) at 1, 2, and 3 minutes after administration, and the rate of change of PI.;ED50 of Ciprofol and Propofol.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactJi Leting
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed