Disorder of Consciousness
Conditions
Interventions
Simple Sound Stimulation Group and Familiar Person's Voice Stimulation:The conversation sessions followed a structured design, encompassing the review of personal information, sharing of fond memories
Combined Auditory and Active TMS Stimulation:The iTBS intervention was administered using a Magstim Rapid2 Plus 1 TMS device equipped with a double-cone 8-coil, integrated with the Brainsight 2.0 neur
Combined Auditory and Sham TMS Stimulation:Received the identical protocol but using a sham TMS coil.
Sponsors
Yancheng First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Basic Criteria: Aged 18-80 years; coma duration of 7-90 days; Glasgow Coma Scale (GCS) score of 3-8; Revised Coma Recovery Scale (CRS-R) score of 5-15; and relatively stable vital signs. 2. Imaging Requirements: Cranial CT or MRI demonstrating relatively intact brain structure, absence of severe damage in the prefrontal cortex and thalamic regions, and no significant signs of cerebral herniation or increased intracranial pressure. 3. Additional Criteria: Informed consent signed by family members; life expectancy >= 3 months; and ability to cooperate with completing the relevant examinations.
Exclusion criteria
Exclusion criteria: 1. Device-related factors: including implanted electronic devices (e.g., cardiac pacemakers, defibrillators), intracranial metal objects, or inner ear implants/cochlear implants. 2. Disease-related factors: including a history of epilepsy or epileptiform discharges on EEG; severe cardiac, hepatic, or renal dysfunction; malignant tumors or a life expectancy of <6 months; and a history of severe psychiatric disorders. 3. Other factors: such as pregnancy or lactation; current participation in other clinical trials; and unwillingness of family members to provide consent for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRS-R Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Mini-Mental State Examination;Fugl-Meyer Assessment of Motor Recovery;Berg Balance Scale;Functional Independence Measure;Modified Rankin Scale;Electroencephalogram;Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactLu Zhongqian
Yancheng First People's Hospital
Outcome results
None listed