Geographic heterogeneity and mechanisms of NETs-mediated tumor microenvironment remodeling in early-stage lung adenocarcinoma

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600126977

Enrollment

Unknown

Registered

2026-06-22

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early-stage lung adenocarcinoma

Interventions

Observational group:None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Postoperative pathological diagnosis confirming stage I lung adenocarcinoma; 2. Treatment-naïve, with no preoperative radiotherapy, chemotherapy, targeted therapy, or immunotherapy; 3. Long-term local residence history of >=10 years; 4. Aged 18–80 years, voluntarily sign informed consent; 5. Qualified tissue and blood samples, and complete clinical data.

Exclusion criteria

Exclusion criteria: 1. History of prior malignant tumor or combined with other primary cancers; 2. Autoimmune diseases, active infection, or severe cardiopulmonary diseases; 3. Unclear long-term residence; 4. Unqualified specimens or refusal to sign informed consent; 5. Missing clinical data that may affect analysis.

Design outcomes

Primary

Measure	Time frame
Demographic and clinical pathological characteristics of patients;Expression levels of NETs-related markers in tumor tissues;Immune microenvironment-related markers in tumor microenvironment;Peripheral inflammatory cytokines and circulating NETs levels;Immune cell subpopulation characteristics derived from single-cell sequencing;	—

Countries

China

Contacts

Public ContactPeng Dongge

The Second Affiliated Hospital of Hainan Medical University

1453779508@qq.com+86 898 7881931

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 3, 2026