Skip to content

Effect of palonosetron on postoperative nausea and vomiting in children following tonsillectomy and adenoidectomy under general anesthesia: a randomized controlled prospective trial

Effect of palonosetron on postoperative nausea and vomiting in children following tonsillectomy and adenoidectomy under general anesthesia: a randomized controlled prospective trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126972
Enrollment
Unknown
Registered
2026-06-22
Start date
2026-06-26
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting following adenotonsillectomy

Interventions

SGB group:After routine general anesthesia induction for tonsillectomy and adenoidectomy, 3 mL of 1% lidocaine was injected perineurally to the stellate ganglion.
Control group:After routine general anesthesia induction for tonsillectomy and adenoidectomy, stellate ganglion block was not performed.

Sponsors

Guangzhou Women and Children's Medical Center Liuzhou Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. Aged 36–72 months; 2. Parents agreed to participate in this study and signed the informed consent form; 3. ASA physical status I–II; 4. Patients undergoing tonsillectomy and adenoidectomy under sevoflurane anesthesia.

Exclusion criteria

Exclusion criteria: 1. Parents of the child refused to sign the informed consent form; 2. The child had symptoms of pneumonia, asthma, bronchitis, or upper respiratory tract infection within two weeks before surgery; 3. The child had a history of allergy to any drug used in this clinical trial; 4. Children with psychological or neurological disorders, or a history of psychotropic or anticonvulsant drug use; 5. Children with developmental delay, attention deficit disorder, or hearing impairment; 6. Infection at the puncture site; 7. Atrioventricular block.

Design outcomes

Primary

MeasureTime frame
Incidence of PONV at 24 h;

Secondary

MeasureTime frame
PONV score;Postoperative pain score;

Countries

China

Contacts

Public ContactJing Hu

Guangzhou Women and Children's Medical Center Liuzhou Hospital

15077202268@139.com+86 150 7720 2268

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 3, 2026