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Aspirin hyporesponsiveness prediction model for high-risk pregnant women with preeclampsia

Construction of a prediction model of aspirin hyporesponsiveness in high-risk pregnant women for preeclampsia based on genetic polymorphism and pharmacodynamic indicators

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126971
Enrollment
Unknown
Registered
2026-06-22
Start date
2026-06-22
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia

Interventions

Case series:none
control group:none

Sponsors

Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-45 years; 2.Single pregnant women; 3.Clinically assessed to be at high risk of preeclampsia and requiring low-dose aspirin prophylaxis; 4.Women who have registered with our hospital, undergone regular prenatal check-ups, and plan to give birth at our hospital; 5.Pregnant women who voluntarily participate in this study and sign the informed consent form;

Exclusion criteria

Exclusion criteria: 1.Gestational age exceeding 16 weeks at enrollment; 2.Allergy or contraindication to aspirin or other non-steroidal anti-inflammatory drugs (such as active bleeding, severe peptic ulcer); 3.Individuals with clear anticoagulant indications requiring anticoagulant therapy; 4.Individuals with comorbidities affecting platelet function, such as cardiovascular disease and autoimmune disease; 5.Unable to provide complete prenatal care records; 6.Significant fetal structural abnormalities or fetal malformations;

Design outcomes

Primary

MeasureTime frame
preeclampsia;predictive performance;

Secondary

MeasureTime frame
model extrapolation;

Countries

China

Contacts

Public ContactChen Yi

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

bjfcyycy@sina.com+86 10 52272799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 3, 2026