Acute appendicitis
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older; 2. Uncomplicated acute appendicitis (UAA) suspected based on clinical presentation and definitively diagnosed by radiological imaging (ultrasound (US)/computed tomography (CT)/magnetic resonance imaging (MRI)), with the presence of appendicolith. UAA is defined by the typical symptoms, signs, and imaging findings of acute appendicitis without evidence of perforation, gangrene, abscess/phlegmon, or generalized peritonitis; 3. Written informed consent signed by patients or their family members.
Exclusion criteria
Exclusion criteria: 1. Imaging findings suggestive of appendiceal mucocele or suspected appendiceal neoplasm, or other possible acute abdominal conditions; 2. Immunodeficiency (e.g., absolute neutrophil count < 500/mm³, chronic use of immunosuppressive drugs, active chemotherapy, or AIDS); 3. Women who are pregnant or lactating; 4. Allergy or contraindication to proposed antibiotics or laxatives; 5. Initiation of non-operative management with two or more doses of intravenous antibiotics at an outside institution; 6. Intestinal tuberculosis, or inflammatory bowel disease requiring active medical treatment, or severe intestinal adhesions; 7. Severe organ dysfunction or coagulopathy precludes safe tolerance of colonoscopy or is contraindicated; 8. Malignancy requiring active treatment; 9. Any concurrent illness mandating hospitalization or emergent intervention; 10. Another infection that requires treatment with systemic antibiotics; 11. Patients who are expected to be unable to comply with the study protocol or complete the one-year follow-up; 12. Previous episode of appendicitis; 13. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with treatment success (initial treatment success and the absence of recurrence) at 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with at least one complication within 1 year;Number and duration of hospital admissions per person within 1 year;Days absent from work or school due to illness per person within 1 year;Number of clinic visits or emergency room visits per person within 1 year;Shift in the distribution of Visual Analogue Scale (VAS) pain score at 48 hours;EQ-5D-5L at 1 year;Decision Regret Scale at 1 year; | — |
Countries
China
Contacts
Public ContactXin Yang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed