Mental disorders associated with psychological trauma
Conditions
Interventions
Experimental group:Eye Movement Desensitization and Reprocessing (EMDR) combined with targeted memory reactivation (TMR) during rapid eye movement sleep period.
Control group:EMDR + REM-phase pseudo-stimulation
Sponsors
Beijing Huilongguan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients group: (1) Patients diagnosed with post-traumatic stress disorder, depressive disorder, anxiety disorder, bipolar disorder or other mental disorders according to ICD-10; (2) Aged 12–18 years; (3) A positive screening result on the CTQ scale, i.e. a score of =13 on the emotional abuse subscale, or >=10 on the physical abuse subscale, or =8 on the sexual abuse subscale, or =15 on the emotional neglect subscale, or >= 10 on the physical neglect subscale; (4) The patient agrees to participate in this study and has signed an informed consent form. 2. Inclusion criteria for healthy control group: (1) did not meet the diagnostic criteria for any psychiatric disorder according to ICD-10; (2) were matched to the patient group for age and educational level; (3) were aged 12–18 years; (4) agreed to participate in the study and provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for patients group: (1) Patients with schizophrenia, alcohol use disorder or substance use disorder; (2) Use of benzodiazepines or other sleep-inducing medication during the period from one week prior to the start of the study until the end of the study period; (3) Consumption of alcohol or coffee during the study period; (4) Presence of suicidal or self-harming thoughts; (5) History of neurological disorders or recent history of severe head trauma with loss of consciousness; (6) Irregular sleep-wake patterns (e.g., night shifts, jet lag) and sleepwalking; (7) Participation in, or current participation in, other non-pharmacological treatments such as repetitive transcranial magnetic stimulation, non-convulsive electroconvulsive therapy or cognitive behavioural therapy within the past three months. 2. Exclusion criteria for the healthy control group: (1) Organic brain disease; (2) Severe systemic disorders; (3) Psychiatric illness or seizure risk; (4) History of suicidality or self-harm; (5) Substance dependence; (6) Circadian rhythm disruption or sleepwalking; (7) Presence of metal implants, electronic devices, or any other contraindications to magnetic resonance imaging (MRI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective sleep structure parameters;Symptoms of trauma; | — |
Secondary
| Measure | Time frame |
|---|---|
| The strength of functional connectivity within and between key brain networks;Subjective sleep measures;Spectral characteristics of resting-state electroencephalograms;EEG parameters during task performance;skin conductance response;Sleep Diary;PSG's objective indicators;Resting-state and task-based EEG;Brain connectivity; | — |
Countries
China
Contacts
Public ContactLi Xiaohong
Beijing Huilongguan Hospital, Capital Medical University
Outcome results
None listed