Hypothyroidism and Hyperthyroidism
Conditions
Interventions
Gold Standard:Clinical outcomes (Complete thyroid function tests)
Index test:A risk prediction model for thyroid dysfunction adverse events associated with antineoplastic agents.
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years at the time of initial treatment. 2. Histologically or cytologically confirmed malignancy. 3. First-ever treatment with novel antitumor agents (including but not limited to immune checkpoint inhibitors, tyrosine kinase inhibitors, and antibody–drug conjugates) at our institution between January 1, 2019 and December 31, 2025. 4. Availability of at least one thyroid function assessment (including TSH, FT3, and FT4) performed at baseline (prior to treatment initiation) and/or during the treatment period.
Exclusion criteria
Exclusion criteria: 1.Patients with a pre-existing diagnosis of thyroid dysfunction (including hyperthyroidism, hypothyroidism, and thyroiditis) prior to the initiation of novel antitumor therapy, or those receiving concurrent thyroid hormone replacement or antithyroid medication. 2. Receipt of neck radiotherapy or surgery with potential impact on thyroid function within 30 days prior to the first dose of study medication. 3. Concurrent use of non-antitumor agents known to cause thyroid dysfunction (e.g., amiodarone, interferon). 4. Incomplete key clinical data (e.g., medication administration records, follow-up information) that precluded meaningful analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete thyroid function tests (TFTs);Independent risk factors for the development of DTD.;Signal strength of the association between novel antineoplastic agents and DTD.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area Under the Receiver Operating Characteristic Curve, AUC/ROC;Model calibration; | — |
Countries
China
Contacts
Public ContactHui Wu
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed