postoperative nausea and vomiting (PONV)
Conditions
Interventions
Sufentanil Group(Group S):Sufentanil is used for general anesthesia induction, intraoperative redosing, bridging, and postoperative analgesia.
Oliceridine Group(Group O).:Oliceridine is used for general anesthesia induction, intraoperative redosing, bridging, and postoperative analgesia.
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Obtaining informed consent. 2.Patients undergoing elective lumbar fusion surgery with 1–2 levels resected and operative duration of 1–3 hours. 3.Patients identified as at high risk for PONV according to the Apfel score (female, non-smoker, history of PONV/motion sickness, postoperative opioid use); those with 3–4 risk factors are classified as high-risk. 4.ASA physical status II–III; 5.Aged 18–65 years. 6.BMI 18–28 kg/m².
Exclusion criteria
Exclusion criteria: 1.History of allergy to oliceridine. 2.Use of other antiemetics or glucocorticoids within 24 hours before surgery. 3.Presence of severe underlying diseases, such as cardiovascular/cerebrovascular disease, respiratory disease, or severe liver/kidney dysfunction. 4.Poorly controlled diabetes or hypertension. 5.Gastrointestinal obstruction. 6.Patients with opioid addiction. 7.Inability to communicate normally (e.g., hearing impairment, language comprehension disorder, or psychiatric illness).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24?h postoperative nausea and vomiting (PONV) incidence.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators;Gut Microbiota;Opioid consumption (intraoperative and postoperative).;Frequency and severity of PONV within 24 hours postoperatively.;Adverse events; | — |
Countries
China
Contacts
Public ContactQ Liangchao
The First Affiliated Hospital of Nanchang University
Outcome results
None listed