Hearing-loss–related spatial hearing and auditory cognitive abnormality
Conditions
Interventions
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: General Inclusion Criteria: 1.Aged >= 18 years. 2.Possession of basic reading comprehension abilities and the capacity to complete study procedures independently or under investigator guidance. 3.Willingness to participate in the study and provision of written informed consent approved by the Institutional Review Board (IRB). Group-Specific Inclusion Criteria for Normal Hearing Group: 1.Self-reported normal hearing without hearing-related complaints. 2.Bilateral pure-tone audiometry (0.5, 1, 2, and 4 kHz) with a mean air-conduction threshold = 20 dB HL. 3.Signal-to-noise ratio (SNR) loss = -2 dB on the Mandarin Quick Speech-in-Noise test (M-QuickSIN). Group-Specific Inclusion Criteria for Hearing Loss Group: 1.Self-reported hearing-related complaints, including hearing decline, tinnitus, or difficulty hearing in noisy environments. 2.Meeting at least one of the following criteria: (1) Mean air-conduction threshold > 20 dB HL at 0.5, 1, 2, and 4 kHz in at least one ear on pure-tone audiometry; or (2) Signal-to-noise ratio (SNR) loss > -2 dB on the Mandarin Quick Speech-in-Noise test (M-QuickSIN).
Exclusion criteria
Exclusion criteria: 1. Subjects with active otitis externa, otitis media, acute episode of Meniere's disease, diagnosed acoustic neuroma, or other definite structural lesions of the central auditory pathway; 2. Subjects with a medical history of neurological or psychiatric disorders including but not limited to epilepsy (photosensitive epilepsy included), uncontrolled severe vertigo, stroke, Parkinson's disease, severe anxiety or depression; 3. Subjects with a history of severe or uncontrolled motion sickness, or those who experience severe adverse reactions such as intense vertigo, nausea and vomiting during VR adaptation trials; 4. Subjects whose scores on the Mini-mental State Examination (MMSE) are lower than the education-adjusted cut-off value; 5. Subjects with severe uncorrected visual impairments or illnesses severely restricting upper limb or neck movement, which render them unable to operate VR equipment or cooperate with tests; 6. Pregnant women, breastfeeding women or those planning to become pregnant; 7. Subjects concurrently participating in other interventional clinical trials that may affect audiological or cognitive function assessments; 8. Any other conditions judged by the researchers to potentially compromise study safety, data quality or subjects' rights and interests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy Rate of Sound Localization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Root Mean Square;pure-tone audiometry;Speech-recognition scores under noise; | — |
Countries
China
Contacts
Public ContactKe Zhang
Peking University Third Hospital
Outcome results
None listed