Decreased Cardiorespiratory Fitness and Elevated Breathing Reserve
Conditions
Interventions
control group:None
intervention group:inspiratory muscle trainning
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 64 years (inclusive). 2.No regular exercise habits. 3.Completion of a cardiopulmonary exercise test (CPET) with a respiratory exchange ratio (RER) >= 1.1. 4.VO2peak 49.9% for males or > 57% for females. 6.Provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of infectious diseases. 2.History of coronary artery disease, heart failure, pulmonary hypertension, valvular heart disease, cardiomyopathy, severe ventricular arrhythmia, myocarditis, or pericarditis. 3.Presence of severe respiratory diseases, such as chronic obstructive pulmonary disease or severe asthma. 4.Uncontrolled hyperthyroidism or hypothyroidism. 5.Severe anemia. 6.Severe electrolyte disturbances. 7.Severe hypertension. 8.Uncontrolled diabetes mellitus. 9.Abnormal liver function, renal function, or cardiac enzymes. 10.Abnormal findings on electrocardiogram, echocardiogram, or carotid ultrasound. 11.Presence of absolute contraindications to exercise testing. 12.Occurrence of abnormal cardiovascular or respiratory responses during exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peak oxygen uptake (VO2peak); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal inspiratory pressure (MIP);Breath reserve; | — |
Countries
China
Contacts
Public ContactWei Zhao
Peking University Third Hospital
Outcome results
None listed