Lung cancer
Conditions
Interventions
Hydromorphone group:Intravenous injection of 0.015 mg/kg hydromorphone when closing the chest cavity
Sufentanil group:Intravenous injection of 0.15ug/kg sufentanil when closing the chest cavity
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 65 years old; 2. ASA levels I-III; 3.BMI 18~28 kg/m^2; 4.Patients undergoing elective general anesthesia thoracoscopy surgery; 5.Patients who have signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1.History of mental illness, chronic pain, alcohol abuse, or long-term use of analgesics, sedatives, antidepressants, anxiolytics, and nonsteroidal anti-inflammatory drugs; 2.Severe liver and kidney dysfunction; 3.Allergic to relevant opioid drugs; 4.Use monoamine oxidase inhibitors, antidepressants, or antiepileptic drugs within 15 days before surgery; 5.Use sedatives, analgesics, or antiemetic drugs within 24 hours before surgery; 6.Pregnant or lactating women; 7.Patients who are not suitable for clinical research due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of compressions of postoperative analgesia pump;Postoperative analgesic pump drug consumption;Remedial analgesia rate;Adverse reaction incidence rate;PACU wake-up time;Postoperative sleep quality;Postoperative emotional changes;The degree of interference of postoperative pain on activities;Postoperative incidence of pulmonary complications;Postoperative hospitalization days;Postoperative serum levels of IL-6 and IL-8; | — |
Countries
China
Contacts
Public ContactWang Hongqian
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed