sepsis
Conditions
Interventions
Healthy Control Group:None
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for the sepsis patient group: 1. Diagnostic criteria: Must meet the diagnostic criteria for sepsis or septic shock as defined in the "International Consensus on the Third Edition of Definitions for Sepsis and Septic Shock". 2.Inclusion criteria for the sepsis patient group:2. Age range: 18 years old <=age <=75 years old. 3.Inclusion criteria for the sepsis patient group:3. Onset time: At the time of enrollment, it must be within 48 hours after the diagnosis of sepsis. 4.Inclusion criteria for the sepsis patient group:4. Informed consent: The patient himself or his legal authorized representative must voluntarily sign a written informed consent form. 5.Inclusion criteria for the healthy control group: 1. Health status: Through health questionnaires and routine physical examinations, there were no acute or chronic infectious diseases, autoimmune diseases, active malignant tumors, severe liver, kidney or blood system diseases, etc. 6.Inclusion criteria for the healthy control group:2. Age and gender matching: The age was matched with that of the case group (+/-5 years), and the gender ratio was similar. 7.Inclusion criteria for the healthy control group:3. Informed consent: The volunteers themselves voluntarily signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with major underlying diseases: Those with severe liver cirrhosis (Child-Pugh C grade), end-stage renal disease (relying on dialysis), NYHA cardiac function grade IV, diagnosed hematological malignancies, after solid organ or hematopoietic stem cell transplantation, and those requiring long-term use of immunosuppressive agents. 2. Individuals with special infection conditions: Those diagnosed with human immunodeficiency virus (HIV) infection or active tuberculosis. 3. Individuals with special physiological or pathological conditions: Pregnant or lactating women. 4. Sample collection limitations: There are cases where it is difficult to establish an intravenous access, or where severe coagulation disorders prevent the collection of sufficient and qualified blood samples. 5. Other circumstances that may interfere with the research results: Those who received blood products containing white blood cells within 24 hours before enrollment; any other situations that the researcher deems may affect the assessment of immune function or expose the subjects to unacceptable risks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ROCK1/2;APACHE II Score;SOFA score; | — |
Countries
China
Contacts
Public ContactHanbin Wang
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Outcome results
None listed