Surgical indications for lumbar fusion: lumbar disc herniation, lumbar spondylolisthesis, and lumbar spinal stenosis, with the involved levels restricted to 1–2 segments.
Conditions
Interventions
Sufentanil Group(Group S):Sufentanil is administered for induction and maintenance of general anesthesia and for postoperative analgesia
Oliceridine Group(Group O):Oliceridine is administered for induction and maintenance of general anesthesia and for postoperative analgesia
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 65 years, regardless of gender; 2.American Society of Anesthesiologists (ASA) physical status classification II–III; 3.Patients scheduled for elective lumbar fusion surgery under general anesthesia (1–2 spinal levels, estimated operative time 1–3 hours); 4.BMI 18–28 kg/m^2; 5.No preoperative sleep disturbance (PSQI score <= 7); 6.Signed informed consent, willing and able to comply with study assessments;
Exclusion criteria
Exclusion criteria: 1.Allergy or contraindication to oliceridine or opioid medications; 2.Severe dysfunction of vital organs (e.g., liver function Child-Pugh Class C, renal failure requiring dialysis, heart failure within the past 6 months, etc.); 3.Preoperative long-term opioid therapy or history of substance abuse; 4.Long-term use of psychotropic medications or cognitive impairment that precludes cooperation with assessments; 5.Preoperative Pittsburgh Sleep Quality Index (PSQI) > 7 (indicating sleep disturbance) or presence of sleep-related disorders (e.g., obstructive sleep apnea);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbance (PSD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Restoration Quality;Incidence of adverse reactions;Dration time, PACU stay duration, hospitalization duration;Use of postoperative adjuvant analgesic medications;VAS pain scores in both resting and active states;sleep quality;PSQI grade; | — |
Countries
China
Contacts
Public ContactQU Liangchao
The first affiliated hostipal of nanchang university
Outcome results
None listed