breast cancer
Conditions
Interventions
Breast Cancer with Good Grip Strength Recovery Group (Group B):None
Breast cancer with persistent grip loss group (group A):None
Sponsors
Jing'an District Central Hospital of Shanghai
Eligibility
Sex/Gender
Female
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Group A: Breast cancer with persistent grip weakness Group: (1) Women diagnosed by histopathology with primary unilateral breast cancer, aged 20-75 years. Breast cancer stages were not limited (stages I to III could be included); stage IV (metastatic) patients were not included in this study; (2) Completed breast cancer surgery (no surgical method restricted: breast-conserving surgery or total mastectomy), with a postoperative time of >= 1 month (regardless of whether chemotherapy was completed); (3) Discussion of criteria for determining grip strength decline (the following "grip strength" refers to using a Jamar electronic grip strength scale, following ASHT standardized posture measurement, and taking the maximum value three times): Case 1: Surgical side = dominant hand, the affected side (dominant hand) grip strength = 1 month post-surgery (regardless of whether chemotherapy was completed); (3) Criteria for determining grip strength recovery Discussion by situation: Case 1: Surgical side = dominant hand, affected side (dominant hand) grip strength >= healthy side (non-dominant hand) grip strength 85%. That is, postoperative grip strength on the affected side is not lower than the contralateral baseline, indicating good functional recovery. Case 2: Surgical side ? dominant hand, affected side (non-dominant hand) grip strength >= 80% of healthy side (dominant hand) grip strength. Since the healthy side is naturally about 11.6% stronger than the affected side, reaching 95% of the healthy side is equivalent to returning to the preoperative baseline level, indicating good grip strength recovery; (4) FACIT-F > 40 (no obvious fatigue); (5) Able to understand the research content and cooperate in completing EEG/EMG assessments; (6) Sign the informed consent form; 3.Group C: Healthy control group: (1) healthy women, aged 20-75; (2) Age, gender, and years of education matched to the breast cancer group; (3) No upper limb dysfunction or history of major illness; (4) Able to understand the research content and cooperate in completing EEG/EMG assessments
Exclusion criteria
Exclusion criteria: 1.Preoperative dysfunction, trauma, neuromuscular disease, or lymphedema in the affected upper limb; 2.History of organic shoulder joint disease or neurological disorders; 3.Combined with severe heart, lung, liver, or kidney dysfunction; 4.Severe cognitive impairment or mental illness; 5.Presence of contraindications to cranial trauma, epilepsy, or EEG; 6.Pregnant or breastfeeding women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG-EMG coherence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Score;Heart Rate Variability (HRV);Grip strength;TNF-a;Shoulder Range of Motion;Upper limb muscle strength;IL-6; | — |
Countries
China
Contacts
Public ContactJie Jia
Huashan Hospital, Fudan University
Outcome results
None listed