Pregnancy complicated by Graves' disease (hyperthyroidism)
Conditions
Interventions
"Standard/Conventional" group:None
"Early/low-dose" group:None
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Gravels disease was diagnosed during the early pregnancy (<= 12 weeks), with positive TPOAb and/or TRAb; 2. Age range: 18 - 45 years old; 3. Singleton pregnancy; 4. No known severe cardiovascular, liver or kidney diseases before pregnancy; 5. At least one record of FT4 and TSH tests during the early pregnancy.
Exclusion criteria
Exclusion criteria: 1. Those who had received antithyroid drugs (ATDs) treatment before pregnancy and did not discontinue the medication in the first trimester; 2. Those who had previously undergone radioactive iodine treatment or thyroidectomy; 3. Those with other types of thyroid diseases (such as subclinical hypothyroidism, Hashimoto's thyroiditis); 4. Those with multiple pregnancies; 5. Those who were unable to take oral medications due to severe vomiting in the first trimester; 6. Those with significantly abnormal baseline liver function (ALT/AST > 3 times the upper limit of the normal value); 7. Those with more than 20% of key variables (such as FT4, medication records) missing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main composite outcome: Any of the following adverse maternal and infant events occurs ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to Attainment of Maternal Euthyroidism;Neonatal NICU Admission Rate;Drug-Induced Liver Injury (DILI); | — |
Countries
China
Contacts
Public ContactWang Jingting
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed