Major Depression Disorder
Conditions
Interventions
iTBS group:The target is the left dorsal lateral prefrontal lobe (L-DLPFC), with an intensity of 100% RMT, which is emitted at a frequency of 50HZ, lasting for 2 seconds, with an interval of 8 seconds
rTMS group:rTMS group: The target is the left dorsal lateral frontal lobe (L-DLPFC), the intensity is 100% RMT, the frequency is 10Hz, 7200 pulses are received per day, divided into 2 times, 3,600 pul
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
11 Years to 19 Years
Inclusion criteria
Inclusion criteria: 1. Aged 11 to 19 years; 2. Meeting the DSM-5 criteria for MDD; 3. Absence of current or past psychotic symptoms (e.g., auditory or visual hallucinations); 4. No comorbid schizophrenia, bipolar disorder, obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, or other severe psychiatric conditions; 5. No contraindications to MRI or TMS, including implanted cardiac pacemakers, neurostimulators, artificial metal heart valves, intracranial aneurysm clips, cochlear implants, or other metallic implants.
Exclusion criteria
Exclusion criteria: 1. Alcohol or substance dependence; 2. Severe or unstable medical conditions, including neurological, endocrine, and rheumatic diseases, brain disorders, traumatic brain injury or surgery, and infectious diseases; 3. Recent receipt of rTMS or electroconvulsive therapy; 4. High suicide risk; 5. Contraindications to magnetic resonance imaging (MRI) and iTBS treatment, including cardiac pacemakers, neurostimulators, artificial metallic heart valves, intracranial aneurysm clips, cochlear implants, and other metallic implants (except oral stents); 6. A history of epilepsy or unprovoked seizures; 7. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Rating Scale;Children's Depression Inventory ;Multidimensional Anxiety Scale for Children;Beck Scale for Suicide Ideation ;Connor-Davidson Resilience Scale;Structural MRI;Functional MRI;Arterial spin labeling perfusion imaging ;Spatial N-back Task;Wisconsin Card Sorting Test;Balloon Analog Risk Task;Resting-state electroencephalography (rs-EEG) ; TMS-electroencephalography (TMS-EEG) ;Pittsburgh Sleep Quality Index ; | — |
Countries
China
Contacts
Public ContactDuanwei Wang
Shandong Mental Health Center
Outcome results
None listed