Acute Myocardial Infarction with Sympathetic Activation
Conditions
Interventions
rTMS intervention group:Transcranial Magnetic Stimulation
rTMS sham stimulation group:ShamTranscranial Magnetic Stimulation
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 30–75 years, no restriction on gender; 2.Diagnosed with acute myocardial infarction (AMI) in accordance with the Fourth Universal Definition of Myocardial Infarction (2018 ESC/ACC/AHA/WHF), with typical clinical manifestations, electrocardiographic changes and dynamic elevation of cardiac biomarkers; 3. Received standard reperfusion therapy (thrombolysis or percutaneous coronary intervention, PCI) with stable hemodynamics; 4. Killip class I–II; 5. Evidence of sympathetic activation: resting heart rate >= 90 beats per minute (after excluding interfering factors such as fever, thyroid dysfunction and severe anemia);reduced heart rate variability (e.g., SDNN < 100 ms) or frequency-domain indicators indicating sympathetic predominance (e.g., elevated LF/HF ratio).
Exclusion criteria
Exclusion criteria: Subjects with any of the following conditions shall be excluded: 1. Severe cardiac insufficiency: Killip class = III, or left ventricular ejection fraction (LVEF) < 30%; 2. Contraindications to transcranial magnetic stimulation (TMS), including a history of epilepsy, intracranial surgery or craniocerebral trauma, intracranial/intracranial metallic implants, or implanted pacemakers/defibrillators; 3. Active severe infection, ongoing anti-tumor treatment for malignant diseases, or severe hepatic and renal insufficiency (assessed comprehensively based on clinical manifestations and laboratory parameters); 4. Pregnant or breastfeeding women, or those who plan to become pregnant during the study; 5. Individuals with alcohol or drug dependence, or mental/cognitive disorders associated with poor treatment compliance; 6. Participation in other interventional clinical trials within the preceding 3 months that may affect the interpretation of study results; 7. Prior TMS treatment for other medical conditions; 8. Any other conditions deemed ineligible by the investigators, such as uncontrolled persistent myocardial ischemia, refractory arrhythmia, or the need for urgent surgical intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Standard Deviation of Normal-to-Normal intervals; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum inflammatory factors and neural biomarkers;Adverse event rate;Other frequency domain and time domain indexes of HRV; | — |
Countries
China
Contacts
Public ContactXue Yu
Beijing Hospital
Outcome results
None listed