Primary or metastatic intracranial tumors
Conditions
Interventions
Monitoring negative group (No predefined significant alert events have occurred):None
Monitoring positive group (The amplitude of the motor evoked potential decreases by more than 50%, the amplitude of the somatosensory evoked potential decreases by more than 50%):None
Sponsors
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with intracranial primary or metastatic tumors via imaging (MRI) and postoperative pathology. 2. Age range of 18-75 years. 3. Tumors located in or adjacent to critical functional pathways such as the motor cortex, sensory cortex, language areas, or pyramidal tract. 4. Scheduled for microscopic tumor resection with intraoperative neurophysiological monitoring. 5. Informed consent obtained from the patient or family members, with a signed consent form. 6. Subjects are stratified based on "whether significant warning events occurred during neurophysiological monitoring": those with positive monitoring results are assigned to the positive group, while those with negative monitoring results are assigned to the negative group.
Exclusion criteria
Exclusion criteria: 1. Those who have severe neurological deficits (such as mRS score >3) before surgery and are unable to cooperate in completing basic electrophysiological testing and functional evaluation; 2. Individuals with severe systemic diseases such as heart, lung, liver, and kidney dysfunction, coagulation dysfunction, etc.; 3. History of status epilepticus or presence of metal implants such as pacemakers or deep brain stimulators in the body (affecting monitoring safety); 4. Pregnant or lactating women; 5. Those who are unable to complete postoperative follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological indicators: motor evoked potential (MEP), somatosensory evoked potential (SEP), intraoperative direct electrical stimulation mapping (DCS Mapping), electroencephalogram (cEEG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological function deficit score (NIHSS);Ability to perform daily activities (Barthel Index); | — |
Countries
China
Contacts
Public ContactYuan Li
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;
Outcome results
None listed