Diabetic nephropathy
Conditions
Interventions
Diabetic Nephropathy :None
Sponsors
Zhongshan Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old with no restriction on gender. 2. Diabetic nephropathy group: Patients met the 1999 WHO diagnostic criteria for diabetes (updated in 2021) and were diagnosed with type 2 diabetic nephropathy per Chinese Clinical Guidelines for the Prevention and Treatment of Diabetic Kidney Disease (2021 Edition). Those complicated with acute kidney injury were excluded, and complete clinical medical records were required. 3. Healthy control group: Healthy physical examination participants free of diabetes and primary renal diseases, with normal liver and renal function, routine urine test and blood glucose parameters. 4. All participants voluntarily signed informed consent and could cooperate with serum and urine specimen collection and clinical data collection. 5. No severe cardiac, hepatic or pulmonary failure, as well as no underlying diseases that may interfere with the detection of study biomarkers.
Exclusion criteria
Exclusion criteria: 1. Patients with type 1 diabetes, gestational diabetes and other specific types of diabetes. 2. Renal injury induced by non-diabetic etiologies, including primary glomerulopathy, lupus nephritis, vasculitis-associated nephritis, hypertensive renal damage and polycystic kidney disease. 3. Subjects complicated with acute diabetic complications including diabetic ketoacidosis, hyperosmolar coma or lactic acidosis within the past 3 months. 4. Patients with eGFR =180/110 mmHg). 6. Pregnant or lactating females. 7. Participants enrolled in other clinical trials within 3 months, those with poor compliance or mental disorders unable to complete study follow-up. 8. Cases with incomplete clinical data, medication duration less than 6 months or arbitrary drug withdrawal for more than one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lactic acid in serum;LDHA;histone lactylation;KLF5;Lactic acid in urine; | — |
Secondary
| Measure | Time frame |
|---|---|
| E-cadherin;a-SMA; | — |
Countries
China
Contacts
Public ContactMingliang Fan
Zhongshan Hospital of Xiamen University
Outcome results
None listed