stroke
Conditions
Interventions
Intervention Group:Low-intensity focused ultrasound stimulates the cerebellum to observe changes in patients' upper limb motor function
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged >=18 years and =3 months. 4. Unilateral infarction within the anterior circulation territory, confirmed by CT or MRI. 5. Patients who have received reperfusion therapy, regardless of treatment modality. 6. Fugl-Meyer Assessment of the Upper Extremity (FMA-UE) score <=42. 7. Right-handedness confirmed by the Edinburgh Handedness Inventory. 8. Participants who have adequate comprehension and communication abilities, voluntarily agree to participate in the study, and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of stroke; 2. Severe cognitive impairment or psychiatric symptoms; 3. Presence of other investigational devices or medications currently in use; 4. Bilateral brain lesions or concomitant neurological disorders (e.g., Parkinson’s disease, epilepsy, tumors); 5. Presence of cranial defects; 6. Elevated intracranial pressure; 7. Contraindications to MRI, such as the presence of metal inside or outside the skull, or the presence of implanted devices such as pacemakers or drug pumps; 8. Presence of other comorbidities, such as a history of severe failure of vital organs including the heart, lungs, liver, or kidneys; 9. Individuals unable to complete the full course of treatment, those with adverse reactions to stimulation, or those with poor compliance; 10. Individuals who have undergone similar interventions within the past 6 months or are currently participating in other clinical trials; 11. Pregnant or breastfeeding women, and patients unable to use appropriate contraceptive measures during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer motor function assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-Meyer motor function assessment;Action Research Arm Test (ARAT);modified Rankin Scale (mRS);National Institutes of Health Stroke Scale (NIHSS);the Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD);multimodal magnetic resonance imaging (MRI);electroencephalography;transcranial magnetic stimulation; | — |
Countries
China
Contacts
Public ContactJiao Liqun
Xuanwu Hospital, Capital Medical University
Outcome results
None listed