Stable angina pectoris (CCS grade I-II) with delayed post-exercise blood pressure recovery (SBPRR3 > 0.90)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age =65 years; 2.Confirmed delayed post-exercise blood pressure recovery by cardiopulmonary exercise testing (SBPRR3 > 0.90); 3.Diagnosis of stable angina pectoris, CCS grade I-II; 4.NYHA functional class I-II; 5.Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Acute coronary syndrome, acute myocardial infarction, stroke or transient ischemic attack within the past 3 months; 2.Decompensated heart failure, uncontrolled severe arrhythmia, severe valvular heart disease, obstructive hypertrophic cardiomyopathy, acute myocarditis or pericarditis; 3.Inability to complete exercise testing and training due to musculoskeletal, neurological, peripheral vascular or severe COPD; 4.Resting systolic blood pressure =180 mmHg and/or diastolic blood pressure =110 mmHg; 5.Severe liver or kidney dysfunction or malignancy; 6.Cognitive impairment or mental disorder that precludes compliance with assessment and intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in SBPRR? (?SBPRR?); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in 6-minute walk distance (?6MWD);Incidence of adverse events;Change in E/e' ratio (?E/e');Proportion of subjects with normalized SBPRR? (=0.90) after intervention;Change in 30-second chair stand test (?30s-ST);Change in Patient Health Questionnaire-9 score (?PHQ-9);Change in International Classification of Functioning, Disability and Health (ICF) score (?ICF);Change in Generalized Anxiety Disorder-7 score (?GAD-7);Change in peak oxygen uptake (?peak VO?); | — |
Countries
China
Contacts
Shanghai Geriatric Medical Center