Tracheal Intubation Stress Response
Conditions
Interventions
Sequential Dose Group of Oliceridine Combined with Ciprofol:Intravenous Injection of Oliceridine Combined with Ciprofol
Sponsors
Quanzhou first Hospital,Fujian
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective general anesthesia surgery; 2. Unrestricted age; 3. Body mass index (BMI): 18–28 kg/m^2; 4. American Society of Anesthesiologists (ASA) physical status classification: I–II; 5. Voluntarily signed informed consent, and able to understand and cooperate with the study procedures.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy to oliceridine, ciprofol or other experimental drugs; 2.Patients with severe hepatic and renal dysfunction; 3.Patients with a history of smoking, asthma, chronic bronchitis, upper respiratory tract infection within 2 weeks, or those receiving benzodiazepines or other central nervous system depressants; 4.Patients with known or suspected gastrointestinal obstruction (including paralytic ileus); 5.Patients with sinus bradycardia before anesthesia induction, or potential conditions associated with QT interval prolongation (such as ventricular arrhythmia, untreated hypokalemia, hypomagnesemia, etc.); 6.Patients with mental disorders or cognitive dysfunction; 7.Patients with predictable difficult airway, failed intubation after 3 attempts, or poor tolerance during intubation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inhibitory Effect on Intubation Positive Responses; | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG;Percutaneous finger oxygen saturation (SpO2); | — |
Countries
China
Contacts
Public ContactXie Wenji
Quanzhou first Hospital,Fujian
Outcome results
None listed