Knee Osteoarthritis (KOA)
Conditions
Interventions
Group1:Real stimulation of the OFC and SMA
Group 2:Verum OFC + Sham SMA group
Group 3:Sham OFC +Verum SMA group
Group 4:Sham OFC stimulation + Sham SMA stimulation
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for knee osteoarthritis (referencing the 1986 American Rheumatism Association's criteria for knee osteoarthritis): (1) X-rays show marginal bone formation in the joint; (2) Knee problems (within one month before the visit, pain lasting >=14 days); (3) Synovial fluid: clear, viscous, WBC 40 years; (5) Morning stiffness of the knee = 3 months. 5. K/L grade (radiological diagnosis standard by Kellgren and Lawrence) >= 2; 6. WOMAC pain subscale score >= 40; 7. BPI pain score > 2 within one week of enrollment; 8. BDI score < 14, Hamilton Anxiety Scale score < 14; 9. Complaints of memory decline; 10. Montreal Cognitive Assessment (MoCA) score: illiterate < 14, elementary school < 20, middle school and above < 25; 11. Right-handed; 12. Informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: 1. People with a tendency to bleed; 2. History of knee surgery in the past six months (like arthroscopy) or intra-articular corticosteroid injection in the past three months; 3. Knee pain caused by rheumatic diseases; 4. Having primary or secondary muscle diseases (like idiopathic inflammatory myopathy, progressive muscular dystrophy, glycogen storage disease, etc.); 5. Mental disorders, poor vision, inability to act independently, or unwillingness to cooperate with clinical observation and treatment; 6. Severe organ failure or serious cardiovascular and cerebrovascular system diseases; 7. Women who are pregnant or breastfeeding; 8. Having contraindications for MRI such as non-removable dentures, pacemakers, or taking drugs affecting brain imaging like opioids or benzodiazepines; anyone who meets any of these is not included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety outcomes;Knee joint function;Pain Catastrophizing Scale (PCS);Quality of life (QoL);neuroimaging parameters;Emotional state;Motor function;Blood biomarkers;Cognitive function; | — |
Countries
China
Contacts
Public ContactQianqian Sun
Xiangyang Central Hospital
Outcome results
None listed