Endoscopic Therapy
Conditions
Interventions
Group O:Group O received oliceridine 0.02 mg/kg combined with propofol 1.5 mg/kg
Group S:Group S received sufentanil 0.1 µg/kg combined with propofol 1.5 mg/kg
Sponsors
Lu'an Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients must be between 18 and 65 years of age, with no gender restrictions; 2. Body mass index must be within the range of 18 to 30 kilograms per square meter; 3. American Society of Anesthesiologists physical status classification must be Class I, II, or III ; 4. Scheduled to undergo painless endoscopic mucosal resection (EMR) of the gastrointestinal tract under general anesthesia; 5. Must provide written informed consent prior to participation, indicating voluntary agreement to take part in the study.
Exclusion criteria
Exclusion criteria: 1. Individuals with any contraindication to general anesthesia are excluded from the study 2. Patients who have a known allergy to or contraindication against any of the study medications (including opioids)o r their ingredients will not be enrolled 3. Exclusion applies to patients with a history of craniocerebral trauma, cerebrovascular accidents, or those diagnosed with central nervous system disorders or mental illnesses 4. Patients on chronic therapy with psychotropic agents, opioid analgesics, sedative-hypnotic medications, or non-steroidal anti-inflammatory drugs are ineligible 5. Any patient assessed as having a difficult airway by the attending anesthesiologist will be excluded 6. Subjects who have taken part in another clinical investigation in the 3-month period preceding the current study enrollment are not eligible to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of opioid-induced respiratory depression;visual analogue scale (VAS);QoR15 Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (MAP, HR, SpO2);Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactXu Zhonghou
Lu'an Hospital Affiliated to Anhui Medical University
Outcome results
None listed