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A Randomized Controlled Clinical Trial on the Efficacy of Cognitive Digital Therapeutics in Improving Postoperative Cognitive Dysfunction in OP-CABG Patients

A Randomized Controlled Clinical Trial on the Efficacy of Cognitive Digital Therapeutics in Improving Postoperative Cognitive Dysfunction in OP-CABG Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126812
Enrollment
Unknown
Registered
2026-06-16
Start date
2026-06-30
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Atherosclerotic Heart Disease

Interventions

Digital Cognitive Therapy Group:In addition to standard preoperative preparation, patients in the intervention group will undergo daily digital cognitive training sessions lasting 60 minutes each, sta
Control Group:The control group will receive standard preoperative care only, without any additional cognitive intervention.

Sponsors

Beijing Anzhen Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old; 2. Have completed more than 6 years of education; 3. Patients with coronary heart disease who plan to undergo elective coronary artery bypass grafting (CABG); 4. Have at least 5 days of preoperative preparation time before the surgery; 5. Agree to undergo cognitive function tests and cognitive training and are able to follow the requirements for follow-up.assessments.

Exclusion criteria

Exclusion criteria: 1. Previously diagnosed with dementia or with a Mini-Mental State Examination (MMSE) score of less than 22; 2. Had a history of delirium; 3. Caused by cognitive dysfunction resulting from neurological and psychiatric disorders such as head trauma, brain tumors, stroke, Parkinson's disease, schizophrenia, Alzheimer's disease, anxiety disorder, depression, etc.; 4. Has blindness, deafness, or other reasons preventing normal communication or using cognitive training equipment; 5. Heavy drinking or taking drugs that affect cognitive function (antihistamines, antipsychotics, etc.); 6. Unable to master the use of cognitive training equipment after 2 training sessions, each lasting 30 minutes; 7. Severe liver or kidney dysfunction or critically ill condition with extremely poor prognosis, expected survival period less than 1 month; 8. Previously undergone neurosurgery or had a history of head tumors; 9. Patients with atrial fibrillation, structural heart disease, or infectious endocarditis; 10. Patients who received other surgeries in addition to CABG; 11. Patients currently participating in other clinical studies.

Design outcomes

Primary

MeasureTime frame
Postoperative Cognitive Dysfunction;

Secondary

MeasureTime frame
Major Adverse Cardiovascular Events (MACE);Basic Cognitive Ability Test;Score of the Five-Level Five-Dimensional Health Scale;Simple Intelligence Status Examination Scale score;Montreal Cognitive Assessment;

Countries

China

Contacts

Public ContactHaiyang Li

Beijing Anzhen Hospital Affiliated to Capital Medical University.

ocean0203@163.com+86 10 6445 6868

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 29, 2026