Anxiety Disorder
Conditions
Interventions
Intervention group:Receiving intervention with the Bifidobacterium longum subsp. longum strain dipro-X preparation
Control group:Receiving placebo intervention
Sponsors
Shanghai Children's Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Aged 12 to 18 years old, no limitation on gender; 2.Scoring =25 points on the SCARED scale; 3.Participants and their legal guardians must provide written informed consent for participation in this interventional study and exhibit the ability to understand and comply with the study protocol.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with major depressive disorder; 2. Diagnosed with neuropsychiatric disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, bipolar disorder, intellectual disability, schizophrenia, or a history of epilepsy; 3. History of head trauma, other unstable major physical illnesses, or physical diseases that may cause psychiatric symptoms; 4. Currently receiving psychotherapy and/or psychotropic medication intervention; 5. Obvious suicidal tendency; 6. Intellectual disability; 7. Participation in other clinical intervention studies involving drugs, dietary supplements, probiotics, or prebiotics within the past 3 months; 8. Severe infection or severe trauma as determined by the investigator, or having undergone moderate to major surgery within the past month; 9. Allergy to known ingredients of probiotic products; 10. Other reasons deemed by the investigator as making the subject unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety Scale Score(HAMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression Scale Score;Self-esteem Scale Score;Sleep Quality Scale Score;Gut metabolites;Gut microbiota; | — |
Countries
China
Contacts
Public ContactZhu Daqian
Shanghai Children's Hospital
Outcome results
None listed