Lumbar disc herniation (LDH)Clinical symptoms: Presence of low back and leg pain, accompanied by radiating pain in the lower limbs (along the course of the sciatic nerve) which may be combined with numbness and weakness
Conditions
Interventions
Exposure group:None
The non-exposure group:None
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
25 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for any one of lumbar disc herniation, degenerative lumbar spondylolisthesis, or lumbar spinal stenosis, with symptoms lasting >=3 months, and imaging findings meeting the corresponding grading requirements (e.g., Pfirrmann grade >=III, Meyerding grade >=I); 2. Poor response to standardized non-surgical treatment for >=1 month, with a VAS pain score >=4 points or an ODI lumbar function score =80% (based on official meteorological data); 4. Clear consciousness, able to cooperate with full follow-up and sample collection, no severe organ dysfunction, coagulation abnormalities, or active infection, and able to tolerate lumbar surgery (if required); 5. Aged 40-75 years, long-term residence (>=5 years) in cities such as Zhanjiang, Maoming, and Yangjiang in Western Guangdong, with a history of residing for >=3 months in the past year in non-humid regions with annual average humidity =3 months, and imaging findings meeting the corresponding grading requirements (e.g., Pfirrmann grade >=III, Meyerding grade >=I). (2) Poor response to standardized non-surgical treatment for >=1 month, with a VAS pain score >=4 points or an ODI lumbar function score <=20 points, or progressive disease. (3) If lumbar surgery is performed, the surgery takes place during the dry season in Western Guangdong (October to May of the following year), and the average daily environmental humidity on the day of surgery and within 7 days postoperatively is <80% (based on official meteorological data).
Exclusion criteria
Exclusion criteria: 1.Patients with non-hereditary lumbar spine diseases, such as lumbar tuberculosis, tumors, traumatic fractures, ankylosing spondylitis, rheumatoid arthritis, and congenital lumbar deformities (such as spinal curvature with a Cobb angle of >=10°). 2. Has a history of previous lumbar surgery (including discectomy, spinal canal decompression, and vertebral fusion), or has a lumbar pars defect or true spondylolisthesis (Meyerding grade >= II). 3. Patients with severe neurological disorders (such as post-embolism sequelae, spinal cord injury, peripheral nerve lesion), mental disorders (such as depression, schizophrenia, with MMSE score less than 24), or cognitive dysfunction, who are unable to accurately report symptoms and cooperate with follow-up; 4. Within the past 3 months, there has been an acute infection, severe trauma, or any other major surgery (such as abdominal surgery or joint replacement surgery), which may affect postoperative recovery and the evaluation of therapeutic efficacy; 5. Allergic to the anesthetic drugs used during the surgery, or having uncontrolled underlying diseases (such as hypertension with systolic blood pressure >= 180 mmHg, diabetes with HbA1c > 8%, severe osteoporosis with T value = 30%. 7. Participated in other concurrent clinical studies related to DLSD, or used drugs that might affect inflammatory indicators within the past 1 month (such as glucocorticoids, immunosuppressants); 8. Pregnant women, lactating women, or those with other conditions that make them unsuitable for participating in the study (such as a survival period of less than 2 years for a malignant tumor).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| JOA score;30-day deep surgical site infection rate in the exposure group (surgery performed from June to September with average daily humidity >=80%) versus the control group (surgery performed from October to May with average daily humidity <80%); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score; | — |
Countries
China
Contacts
Public ContactWei Bo
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed