Asthma
Conditions
Interventions
Intervention group:HEPA air purifier (PuraAura, HK), placed in sleeping area, operated continuously for 24 weeks
Control group:Sham air purifier (no HEPA filtration), identical in appearance and noise, operated continuously for 24 weeks
Sponsors
The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
5 Years to 17 Years
Inclusion criteria
Inclusion criteria: For Child Participant: 1. Chinese children aged 5–17 years; 2.Families residing in compromised housing conditions, e.g. SDUs lacks windows/ range hood, or using gas strove (will undergo initial screening to determine their eligibility for this study); 3. Physician-diagnosed moderate-to-severe asthma with persistent symptoms (=two daytime episodes per week/ two nocturnal awakenings per month for a period of at least three months) in the past year, with regular use of moderate to high doses of inhaled corticosteroids or ICS/LABA combination for =4 weeks (NAEPP EPR-4 Step 3-4 criteria); 4. >=2 exacerbation in the past year; 5.Resident =5 days and nights every week in the home; 6.Can read / understand Chinese/English. For Primary caregiver (Qualitative Interview): 1.Lowest air purifier adherence at week 24; 2.Highest air purifier adherence at week 24; 3.Lowest air purifier adherence maintained at week 28; 4.Highest air purifier adherence maintained at week 28 will be recruited.
Exclusion criteria
Exclusion criteria: 1. Individuals will be excluded if they have other respiratory diseases, use steroids for non-asthma conditions, are undergoing allergen immunotherapy/asthma biological therapy, smoke, had recent asthma-related hospitalizations/A&E visits, have any serious chronic illnesses, were born before 34 weeks gestation or with birth weight <=2.5 kg, or have a congenital deformity. 2. Consent to participate was not given 3.Families who owned air cleaners, planning to move within the 28-week study duration, or those who cannot communicate in Chinese/ English 4.For families with more than one eligible child, the child with more exacerbation events in the past year will be invited to join this study (other children are excluded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of acute asthma attacks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exhale carbon monoxide;Pulmonary function;Asthma Control;Quality of life of children;Urine metabolomics;Indoor air quality; | — |
Countries
China
Contacts
Public ContactCrystal Ying Chan
The Chinese University of Hong Kong
Outcome results
None listed