At initial presentation, the patient had respiratory symptoms (e.g., cough, dyspnea, chest tightness) but had not been definitively diagnosed with asthma
Conditions
Interventions
Gold Standard:The gold standard for diagnosing asthma refers to the 'GINA (Global Initiative for Asthma) Global Strategy for Asthma Management and Prevention (2025 edition)' and China's 'Guidelines fo
Index test:Asthma Diagnosis Prediction Model Based on Quantitative Chest CT Parameters
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 75 years, regardless of sex; 2.Presence of respiratory symptoms at initial presentation (e.g., cough, dyspnea, chest tightness), without a confirmed diagnosis of asthma at that time; 3.Completion of chest CT scan prior to diagnosis, with image quality meeting the requirements for analysis; 4.Underwent bronchodilator reversibility testing or bronchial provocation testing, with definitive results available; 5.No evidence of infectious consolidation, exudation, or other confounding pulmonary lesions on CT imaging; 6.No signs of infection in complete blood count (e.g., normal total leukocyte and neutrophil counts); 7.Availability of complete pulmonary function test results, inflammatory biomarkers (e.g., blood eosinophils [EOS], FeNO), and basic demographic information.
Exclusion criteria
Exclusion criteria: 1. Clear diagnosis of other respiratory diseases (like COPD, bronchiectasis, tuberculosis, interstitial lung disease, etc.); 2. History of acute respiratory infection within the past month; 3. CT images are of poor quality, have artifacts, or cannot be analyzed quantitatively; 4. Previous asthma-related treatments (steroids, bronchodilators, etc.) affecting baseline tests; 5. Presence of serious cardiovascular, immune system, or other major systemic diseases; 6. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function parameters;Chest CT imaging parameters;IOS parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Count (CBC);FENO; | — |
Countries
China
Contacts
Public ContactYan Zhou
Shanghai General Hospital
Outcome results
None listed