Heart failure
Conditions
Interventions
Observational group:None
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Typical symptoms and/or signs of heart failure (e.g., dyspnea, edema); 2. Left ventricular ejection fraction (LVEF) >= 50%; 3. First-time hospitalized patients with New York Heart Association (NYHA) functional class II or III; 4. And must meet the criteria for left ventricular diastolic dysfunction/elevated left ventricular filling pressure, including elevated plasma natriuretic peptides [sinus rhythm: B-type natriuretic peptide (BNP) > 35 ng/L and/or N-terminal pro-B-type natriuretic peptide (NT-proBNP) > 125 ng/L; atrial fibrillation: BNP >= 105 ng/L or NT-proBNP >= 365 ng/L], and abnormal findings on resting or stress echocardiography or cardiac catheterization [ratio of early diastolic mitral inflow velocity to early diastolic tissue Doppler annular velocity (E/e') > 14 measured by echocardiography during exercise. Invasive hemodynamic testing: resting pulmonary capillary wedge pressure (PCWP) >= 15 mmHg (1 mmHg = 0.133 kPa) or left ventricular end-diastolic pressure >= 16 mmHg, or stress PCWP >= 25 mmHg].
Exclusion criteria
Exclusion criteria: 1. Patients with severe valvular disease, cardiac arrhythmia, angina pectoris, or pulmonary disease (vital capacity and/or forced expiratory volume in 1 second less than 80% of the age-predicted value); 2. Patients with untreated coronary artery stenosis > 50%; 3. Previous myocardial infarction; 4. Anemia (hemoglobin 150 mmHg or diastolic blood pressure > 100 mmHg; 7. Changes in cardiovascular medication regimen within the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac diastolic function; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 year all cause readmission rate cardiovascular mortality; cardiovascular mortality;Exercise capacity;Quality of life; | — |
Countries
China
Contacts
Public ContactZhang Bing
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed