Skin sclerosis, lichenoid changes
Conditions
Interventions
The cGVHD case group and the non-CGVHD control group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 60 years at our center who voluntarily participate in this study and have signed the informed consent form, having undergone allogeneic hematopoietic stem cell transplantation. The diagnostic criteria refer to the Expert Consensus on the Diagnosis and Treatment of Chronic Graft-versus-Host Disease (cGVHD) (2024 Edition). Patients must not have severe impairment of vital systemic organs, as defined by the following criteria: (1) Creatinine = 2 g/dL; (3) Left ventricular ejection fraction > 50%; (4) Hemoglobin > 9 g/dL and bilirubin < 2.0 mg/dL. (5) Complete blood count, liver and kidney function tests, and coagulation profiles must be within normal limits; (6) Pre-transfusion screening tests and hepatitis B five-item serology must all be negative.
Exclusion criteria
Exclusion criteria: 1. Severe complications or high-risk factors: active bleeding disorders (such as coagulation dysfunction, International Normalized Ratio [INR] > 1.5, or platelet count = 3 or expected survival 8.9 mmol/L); hypertension that cannot be reduced to the following range despite treatment with two or fewer antihypertensive agents (systolic blood pressure 2.5 × upper limit of normal (ULN); direct bilirubin (DBIL) and total bilirubin (TBIL) > 2.0 × ULN; serum creatinine > 1.5 × ULN; use of anticoagulant or antiplatelet medications (except low-molecular-weight heparin). 7. Inability to complete the study as required by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers of cGVHD;Performance indicators of the cGVHD diagnostic model; | — |
Countries
China
Contacts
Public ContactWang Xiaoqi
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed