Skip to content

Dual-Track Multimodal Machine Learning Framework (ECHO) Integrating Clinical Phenotypes, Radiomics, and Multi-Omics for Hepatocellular Carcinoma Prognostic Stratification: A Multicenter Study

Dual-Track Multimodal Machine Learning Framework (ECHO) Integrating Clinical Phenotypes, Radiomics, and Multi-Omics for Hepatocellular Carcinoma Prognostic Stratification: A Multicenter Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126750
Enrollment
Unknown
Registered
2026-06-15
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HCC

Interventions

Sponsors

Dazhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 75 years old, regardless of gender; 2. Patients pathologically diagnosed with hepatocellular carcinoma (HCC), or HCC patients meeting the non-invasive diagnostic criteria of the AASLD/EASL guidelines; 3. Having complete baseline clinical phenotype data and laboratory test results; 4. Having high-quality abdominal enhanced CT or MRI imaging data (slice thickness <=5 mm) within 1 month before treatment, which can be used for extracting radiomics features; 5. Agreeing to provide tissue and/or blood samples for multi-omics (such as metagenomics, transcriptomics, etc.) sequencing analysis; 6. The subject or their legal representative has signed a written informed consent form.

Exclusion criteria

Exclusion criteria: 1. Combined with severe diseases in other systems (such as severe cardiorespiratory failure) or a previous history of other malignancies; 2. Clinical data and medical images are severely lacking or have obvious artifacts, making omics analysis impossible; 3. Poor compliance, with an expected inability to cooperate in completing the web-based patient follow-up system and long-term follow-up; 4. Patients in whom the researcher believes there are other situations not suitable for participating in this study.

Design outcomes

Primary

MeasureTime frame
Overall survival;Recurrence-Free Survival, RFS;

Secondary

MeasureTime frame
C-index;Area Under the ROC Curve;Calibration curve;DCA;

Countries

China

Contacts

Public ContactFanxin Zeng

Dazhou Central Hospital

949982418@qq.com+86 181 6309 4852

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 29, 2026