Stable Coronary Artery Disease
Conditions
Interventions
Conventional Management Group:Treatment strategies were recommended based on stenosis severity, pre-test probability, and functional test results: For patients with 50-70% stenosis, if the pre-test pr
if the pre-test probability was =15%, it was advised to recommend treatment strategies considering functional test results. For patients with CCTA-indicated 70-90% stenosis, clinicians could directly
MCG Group:Based on MCG results, either ICA or optimal medical therapy was recommended.
Sponsors
Beijing Anzhen Hosptial, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years, both genders; 2. Patients with stable coronary artery disease (CAD); 3. CCTA indicates at least one major epicardial vessel (vessel diameter >=2.5 mm) with 50–90% stenosis. Patients with 50–69% stenosis must have typical or atypical angina pectoris, while patients with 70–90% stenosis are not restricted by the presence of chest pain symptoms. *Note: The three characteristics of chest pain are: (1) chest discomfort lasting less than 15 minutes; (2) induced by physical activity or emotional stress; (3) relieved by rest or nitrates. Typical angina pectoris: all three characteristics present; atypical angina pectoris: two characteristics present; non-anginal chest pain: =1 characteristic present.* 4. Willing to participate voluntarily in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previous myocardial infarction, PCI, CABG, or coronary angiography indicating stenosis >=50% in a major vessel. 2. CCTA indicating left main coronary artery stenosis >50% and/or three-vessel disease. 3. History of cardiac dysfunction (>= NYHA Class III), severe congenital heart disease, valvular heart disease, or cardiomyopathy. 4. Complex arrhythmias, such as frequent atrial premature beats, ventricular premature beats, atrial fibrillation, atrial flutter, etc. 5. History of metal implant placement (including mechanical valves, pacemakers, orthopedic internal fixation plates, drug pumps, etc.). 6. Claustrophobia. 7. Severe thoracic deformity. 8. Active bleeding. 9. Any disease with an expected survival of less than 1 year. 10. Completion of any of the following tests prior to enrollment: exercise ECG, stress echocardiography, stress SPECT, or stress CMR. 11. Any other condition where the investigator considers the patient unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with non-obstructive coronary artery disease on invasive coronary angiography (ICA) within 90 days. :; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major Adverse Cardiovascular Events;Seattle Angina Questionnaire;Total medical expenditure of patients in the study; | — |
Countries
China
Contacts
Public ContactSong Xiantao
Beijing Anzhen Hosptial, Capital Medical University
Outcome results
None listed