Osteoporosis, sarcopenia, osteoarthritis
Conditions
Interventions
Yili Xinhuo Bone Gold Assembly Formula Milk Powder Group:Yili Xinhuo Bone Gold Assembly Formula Milk Powder
Blank control group:none
Sponsors
Chinese Center for Disease Control and Prevention
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 40 to 60 years old. Woman are postmenopausal. 2.Routine physical examination results are normal. 3.There has been no significant change in weight over the past six months. 4.Body Mass Index (BMI) falls within the range of 18.5 - 27.9 kg/m²;
Exclusion criteria
Exclusion criteria: 1. Lactose intolerance or dairy allergy; 2. Having malignant tumors, diabetes, digestive system diseases, or liver and kidney dysfunction that affect protein and amino acid absorption; 3. Pregnant or breastfeeding women; 4. History of surgery in the past three months; 5. People who drink or smoke excessively (according to WHO, excessive drinking is daily alcohol intake >= 40g for men and >= 20g for women, sustained for over 5 years; excessive smoking is smoking for >= 10 years with an average of >= 15 cigarettes per day).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle function evaluation indicators: calf circumference, skeletal muscle mass, grip strength, 6m walking speed, and chair stand test;Joint function: Human N-terminal mid-segment osteocalcin, type I collagen N-terminal propeptide, bone-specific alkaline phosphatase, human type I collagen C-terminal peptide, tartrate-resistant acid phosphatase; | — |
Secondary
| Measure | Time frame |
|---|---|
| SCFAs,Fecal short-chain fatty acids;Element content: serum calcium and phosphorus;BMD;PTH?CT;Gut microbiota;uCTX-II? COMP;Cytokines: IL-6, TNF-a, IL-1ß, IL-10, IL-4;Body weight and body composition; | — |
Countries
China
Contacts
Public ContactLi Min
Chinese Center for Disease Control and Prevention
Outcome results
None listed