Postoperative Delirium
Conditions
Interventions
Experimental group:Gastrodin + Dexmedetomidine
Control group:Saline solution + Dexmedetomidine
Sponsors
The Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
65 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Age 65–74 years 2. ASA (American Society of Anesthesiologists) Physical Status Classification: Grade II–III 3. Scheduled for elective radical gastrectomy under general anesthesia, with an estimated operative duration of 2–4 hours 4. Provided informed consent
Exclusion criteria
Exclusion criteria: 1. Concurrent dementia (MMSE score < 24), Parkinson's disease, or severe depression. 2. History of intracranial surgery or stroke within the past 6 months. 3. Severe hearing/visual impairment that precludes completion of neuropsychological testing. 4. Allergy or contraindication to gastrodin or dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and Subtypes of Postoperative Delirium (POD) within 1–3 Days, 3–5 Days, and 5–7 Days after Surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age, Gender Distribution, Body Mass Index (BMI), ASA Physical Status Distribution, NYHA Functional Class Distribution, Educational Level Distribution, Mini-Mental State Examination (MMSE) Score, Surgical Duration, Anesthesia Duration, Intraoperative Blood Loss;Postoperative Recovery Indicators: Length of Hospital Stay, Time to First Flatus, Time to First Ambulation, Time to Drain Removal;Cerebral Oxygen Saturation ;Numerical Rating Scale (NRS) Score for Postoperative Pain;Incidence of Hypotension (MAP < 65 mmHg), Bradycardia (HR < 50 bpm), and Other Related Adverse Events;7-item Generalized Anxiety Disorder Scale (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) Scores;Plasma or Serum C-Reactive Protein (CRP) Concentration; | — |
Countries
China
Contacts
Public ContactDing Xian
The Affiliated Hospital of Jiangnan University
Outcome results
None listed